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Journal Publications
(*, Corresponding author. †, these authors contributed equally to this work.)

Ito, T, Kubiura-Ichimaru, M, Murakami, Y, Bogutz, AB, Louis Lefebvre, Suetake, I, Tajima, S and Tada, M*: DNMT1 regulates the timing of DNA methylation by DNMT3 in an enzymatic activity-dependent manner in mouse embryonic stem cells. PLOS ONE, 2022 17(1): e0262277.

Okuyama S, Mine A, Nakamura T, Ohasi Y, Seto M, Tada, M. Transgenic HepaRG cells expressing CYP2D6 as an improved model of primary human hepatocytes. Pharmacol Res Perspect. 2022:e00939. doi: 10.1002/prp2.939.



Tada, M*, Hayashi, A., Asano, Y., Kubiura-Ichimaru, M., Ito, T., Yoshii, M., Kimura, H, Matsuda, Y and Oshimura, M: Evidence for divergence of DNA methylation maintenance and a conserved inhibitory mechanism from DNA demethylation in chickens and mammals. Genes & Genomics, 2021; 1–12.

Kubiura-Ichimaru, M., Ito, T., Lefebvre, L and Tada, M*: Cyclic DNA remethylation following active demethylation at euchromatic regions in mouse embryonic stem cells. Chromosome Research, 2020 Nov 17. doi: 10.1007/s10577-020-09645-y.

Ooeda, K, Kubiura, M, Tsuji, S, Okuyama, S, Yamashita, M, Mine, M, Kawamura, F, Ueyama, T, and Tada, M*: A two-dimensional multiwell cell culture method for the production of CYP3A4-expressing hepatocyte-like cells from HepaRG cells. Pharmacol Res Perspect. 2020;8(5):e00652. doi: 10.1002/prp2.652, 2020.


Okuyama, S†, Kawamura, F†, Kubiura M, Tsuji, S, Osaki, M, Kugoh, H, Oshimura, M, Kazuki, Y and Tada, M*: Real-time fluorometric evaluation of hepatoblast proliferation in vivo and in vitro using the expression of CYP3A7 coding for human fetus-specific P450. Pharmacol Res Perspect. 2020; 8(5):e00642. doi: 10.1002/prp2.642, 2020.

Ueyama, T., Tsuji, S., Sugiyama, T., and Tada, M.*: Fluorometric evaluation of CYP3A4 expression using improved transgenic HepaRG cells carrying a dual-colour reporter for CYP3A4 and CYP3A7. Scientific Reports, Sci Rep. 2017 Jun 6;7(1):2874. doi: 10.1038/s41598-017-03146-5.


Tsuji, S., Ohbayashi, T., Kohji Yamakage, Oshimura, M., and Tada, M. *: A cytoplasmic from of Gaussia luciferase provides a highly sensitive test for cytotoxicity. PLOS ONE, 11(5):e0156202. doi: 10.1371/journal.pone.0156202. eCollection, 2016.


Kubiura, M., Ikuo Miura, Tada, M.*:Chromosomal distribution patterns of global 5mC and 5hmC on the ZZ/ZW and XX/XY chromosomes in the Japanese wrinkled frog, Rana rugosa, induced by Tet methylcytosine dioxygenase enzymes. Chromosome Science, 18:15-22, 2015.


Tsuji, S., Kawamura, F., Kubiura, M., Hayashi, A., Ohbayashi, T., Kazuki, Y., Chesné , C., Oshimura, M., and Tada, M. *: Dual-colour fluorescence imaging to monitor CYP3A4 and CYP3A7 expression in human hepatic carcinoma HepG2 and HepaRG cells. PLOS ONE, 9(8): e104123, 2014.


 Kubiura, M., Okano, M., Kimura, H., Kawamura, F., Tada, M.*: Heterochromatin restricts 5mC to 5hmC conversion to euchromatin. Chromosome Research, 20 (7): 837-48, 2012.


 Otsuji, T.G., Kurose, Y., Suemori, H., Tada, M.*, Nakatsuji, N.: Dynamic Link between Histone H3 Acetylation and an Increase in the Functional Characteristics of Human ESC/iPSC-Derived Cardiomyocytes. PLOS ONE 7(9): e45010, 2012.


Takehashi M, Tada M., Kanatsu-Shinohara M, Morimoto H, Kazuki Y, Oshimura M, Tada T, Shinohara T.: Hybridization of testis-derived stem cells with somatic cells and embryonic stem cells. Biol Reprod. 86(6): 178, 2012.


Otsuji, T.G., Minami, I., Kurose, Y., Yamauchi, K., Tada, M.* and Nakatsuji, N. Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to drugs. Stem Cell Research, 4(3):201-213, 2010.


Tada, M.*, Matsumura, H., Kurose, Y., Nakatsuji, N. and Tada, T.: Target chromosomes of inducible deletion by a Cre/inverted loxP system in mouse embryonic stem cells. Chromosome Reseach, 17(4): 443-50, 2009.


Otsuji, T., Matsumura, H., Suzuki, T., Nakatsuji, N., Tada, T. and Tada, M.*: Rapid induction of large chromosomal deletions by a Cre/inverted loxP system in mouse ES cell hybrids. Journal of Molecular Biology, 378(2) 328-336, 2008.


Matsumura, H. †, Tada, M. †, Otsuji, T., Yasucgika, K., Nakatsuji, N., Surani, A. and Tada, T.: Targeted chromosome elimination from ES-somatic hybrid cells following nuclear reprogramming. Nature Methods, 4(1): 23-25, 2007.


Hatano, S. †, Tada, M. †, Kimura, H., Yamaguchi, S., Kono, T., Nakano, T., Suemori, H., Nakatsuji, N. and Tada, T.: Pluripotential competence of cells associated with Nanog activity. Mechanisms of Development, 122(1): 67-79, 2005.


Yamaguchi, S., Kimura, H., Tada, M., Nakatsuji, N. and Tada T.: Nanog Expression in Mouse Germ Cell Development. Gene Expression Patterns, 5: 639-646, 2005.


Kuroda, T., Tada, M., Kubota, H., Kimura, H., Hatano, S., Suemori, H., Nakatsuji N., and Tada, T.: Octamer and Sox elements are required for transcriptional cis-regulation of Nanog gene expression. Molecular Cellular Biology, 25(6): 2475-2485, 2005.


Ohhata, T., Tachibana, M., Tada, M., Tada, T., Sasaki, H., Shinkai, Y. and Sado, T.: X-inactivation is stably maintained in mouse embryos deficient for histone methyl transferase G9a. Genesis, 40(3): 151-156, 2004.


Kimura, H., Tada, M., Nakatsuji, N. and Tada, T.: Histone code modifications on pluripotential nuclei of reprogrammed somatic cells. Molecular Cellular Biology, 24(13): 5710-5720, 2004.


Tada, M., Morizane, A., Kimura, H., Ainscough, J. F. -X, Sasai, Y., Nakatsuji, N. and Tada, T.*: Pluripotency of reprogrammed somatic genomes in embryonic stem hybrid cells. Developmental Dynamics, 227: 504-510, 2003.


Kimura, H., Tada, M., Hatano, S., Yamazaki, M., Nakatsuji, N. and Tada, T.: Chromatin reprogramming of male somatic cell-derived Xist and Tsix in ES hybrid cells. Cytogenet Genome Research, 99: 106-114, 2002.


Tada, M., Takahama, Y., Abe, K., Nakatsuji, N. and Tada, T.: Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Current Biology, 11: 1553-1558, 2001.


Tada, T., Obata, Y., Tada, M., Goto, Y., Nakatsuji, N., Tan, S., Kono, T. and Takagi, N.: Imprint switching for non-random X-chromosome inactivation during mouse oocyte growth. Development 127: 3101-3105, 2000.


Tada, T., Tada, M., Hilton, K., Barton, S. C., Sado, T., Takagi, N. and Surani, M. A.: Epigenotype switching of imprintable loci in embryonic germ cells.  Dev. Genes Evol. 207: 551-561, 1998.


Tada, M., Tada, T., Lefebvre, L., Barton, S. C. and Surani, M. A.: Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells.  EMBO Journal 16: 6510-6520, 1997.


Ainscough, J. F.-X., Koide, T., Tada, M., Barton, S. and Surani, M. A.: Imprinting of Igf2 and H19 from a 130 kb YAC transgene.  Development 124: 3621-3632, 1997.


Kikyo, N., Rideout W.M. 3rd, Tada T., Tada, M. and Surani, M.A.: Mapping of the Fas-associated factor 1 gene, Faf1, to mouse chromosome 4C6 by FISH. Mammalian Genome 8(3): 224-225, 1997.


Kikyo, N., Tada M., Tada, T. and Surani, M.A.: Mapping of the eukaryotic initiation factor, Eif1a, to mouse chromosome 12D-E by FISH. Mammalian Genome 8(5): 376, 1997.


Mise, N., Sado, T., Tada, M., Takada, S. and Takagi, N.: Activation of the inactive X chromosome induced by cell fusion between a murine EC and female somatic cell accompanies reproducible changes in the methylation pattern of the Xist gene. Experimental Cell Research 223: 193-202, 1996.


Kuroiwa, Y., Ishino-Kaneko, T., Kagitani, F., Kohda, T., Li, L.-L., Tada, M., Suzuki, R., Yokoyama, M., Shiroishi, T., Wakana, S., Barton, S. C., Ishino, F. and Surani, M. A.: Peg3 imprinted gene on proximal chromosome 7 encodes for a zinc finger protein.  Nature Genetics 12: 186-190, 1996.


Tada, M., Tada, T., Takagi, N., Hayashizaki, Y., Shibata, H., Hirotsune, S., Okazaki, Y., Muramatsu, M., Sasaki, H., Ueda, T. and Chapman, V.M.: Localization of mouse imprinted gene U2afbprs to A3.2-4 band of chromosome 11 by FISH. Mammalian Genome 5: 655, 1994.


Tada, T., Tada, M. and Takagi, N.: X chromosome retains the memory of its parental origin in murine embryonic stem cells.  Development 119: 813-821, 1993.


Sado, T., Nakajima, N., Tada, M. and Takagi, N.: A novel mesoderm-specific cDNA isolated from a mouse embryonal carcinoma cell line. Develop. Growth Different. 5: 551-560, 1993.


Sato, I., Tada, M., Mikuni, C. and Abe, S.: A combination of lipopolysaccharide and B-cell growth factor increases lymphocyte metaphase yields in B-cell chronic leukemia. Cancer Genet. Cytogenet. 66: 135-136, 1993.


Okada, M., Tada, M., Kanda, M., Masuda, M., Mizoguchi, H., Kazuma, M., Wada, E., Kubota, K. and Nomura, Y.: c-myb gene analysis in T-cell malignancies with del (6q). Cancer Genet. Cytogent. 48: 229-236, 1990.


Tada, M., Okada, M., Kanda, N., Aiba, S., Sasamoto, Y., Ishikawa, C., Kubota, K. and Nomura, Y.: Allele frequencies of MYCL and MYB protooncogenes in unrelated healthy Japanese. Japanese Journal of Human Genetics 34: 251-252, 1989.


Saitoh, M. (Tada, M.の旧姓), Matsuoka, N. and Obara, Y.: Biological systematics of three species of the Japanese Long-tailed field mouse; Apodemus speciosus, A. giliacus and A. argenteus. Zoological Science 6 (5): 1005-1018, 1989.


Saitoh, M. (Tada, M.の旧姓) and Obara, Y.: Meiotic syudies of interracial hybrids from the wild population of the large Japanese field mouse, Apodemus speciosus. Zoological Science 5 (4): 815-822, 1988.


Saitoh, M.(Tada, M.の旧姓) and Obara, Y.: Chromosome banding patterns in five intraspecific taxa of the large Japanese field mouse, Apodemus speciosus. Zoological Science 3 (5): 785-792, 1986.


Asai, Y., Tada, M., Otsuji, T.G., Nakatsuji, N.: Combination of Functional Cardiomyocytes Derived from Human Stem Cells and a Highly-Efficient Microelectrode Array System: An Ideal Hybrid Model Assay for Drug Development. Current Stem Cell Research & Therapy, 5(3): 227-32, 2010.


Tada, T., Kimura, H., and Tada, M.: “Nuclear Reprogramming” and “ Epigenetic Reprogramming”. J. Mamm. Ova Res. 21: 97-104, 2004.


Tada, T. and Tada, M.: Toti-/pluripotential stem cells and epigenetic modifications. Cell Structure and Function 26: 145-156, 2001.




Tada, M.*: Chromosome Engineering in Mouse Embryonic Stem Cells: Addition and Elimination of Targeted Chromosomes. "In METHODOLOGICAL ADVANCES IN THE CULTURE, MANIPULATION AND UTILIZATION OF EMBRYONIC STEM CELLS FOR BASIC AND PRACTICAL APPLICATIONS." ed. by Craig S. Atwood. (INTECH) pp327-342, 2011.


Tada, M. * and Tada, T.: Epigenetic reprogramming of somatic genomes by electrofusion with embryonic stem cells. "Nuclear Reprogramming; Methods and Protocols.” ed. by Steven Pelles  (The Humana Press Inc, USA), pp67-79, 2005.


Tada, M. * and Tada, T.: Nuclear reprogramming of somatic nucleus hybridized with ES cells by electrofusion. "In Nonhuman Embryonic Stem Cell Protocols.” ed. by Kursad Tursen (The Humana Press Inc, USA), pp411-420, 2005.


Tada, M. * and Tada, T.: Electrofusion: Nuclear reprogramming of somatic cells by cell hybridization with pluripotential stem cells. "In Cell Biology: A Laboratory Handbook, 3rd Edition." ed. by Julio Celis, J. (Academic Press, USA), 2005.


Tada, T., Tada, M. and Surani, M.A.: Plasticity of somatic nucleus by epigenetic reprogramming via cell hybridization. "In Principles of Cloning” edited by Cibelli JB., Lanza R., Campbell K and West MD (Academic Press, USA), 2002.


Takagi, N., Tada, M., Shoji, M. and Moriwaki, K.: An X-linked gene governing sperm morphology revealed in laboratory mice consomic for X chromosome from Japanese house mouse, Mus musculus molossinus. "Geneitics in wild mice"edited by Moriwaki F., Shiroishi, T. and Yonekawa, H. (Japan Scientific Societies Press, JPN), 1994.



Reviews (Japanese)


多田政子*: DNA修飾酵素のアクセス許容度から追跡するクロマチンリプログラミング. 月刊細胞52(9): 32–35,2020.


多田政子*: 幹細胞のゲノムインプリンティングとエピジェネティクス. 実験医学 増刊30(10): 54-58, 2012.


黒田貴雄, 多田政子*: 幹細胞の未分化性維持機構. 生化学78(2): 137-141, 2006.


多田政子*: 体細胞の再プログラム化と多能性幹細胞マーカー. Medical Science Digest 30(10): 34-37, 2004.


多田政子*, 多田高: ES細胞・リンパ球—ES融合細胞. Clinical Neuroscience 21(10): 1131-1133, 2003.


多田政子*, 多田高: ES細胞の融合によるリプログラミング. Molecular Medicine 40: 48-56, 2003.


多田政子*, 多田高: ES細胞による体細胞の再プログラム化. 実験医学21(8): 124-129, 2003.


木村博信, 多田政子, 多田高: ES細胞による体細胞ゲノム再プログラム化の分子機構. 現代医療 35(5): 65-70, 2003.


多田高, 多田政子: 生殖細胞の分化過程における核の再プログラム化. 分子細胞治療2 (2): 51-56, 2003.


多田高, 多田政子: ES細胞を用いた拒絶反応の回避-再生医学のさらなる挑戦. 蛋白質核酸酵素47(6): 715-722, 2002.


多田高, 多田政子: 細胞融合による体細胞遺伝情報のリプログラミング. 細胞工学 21: 853-858, 2001.


多田政子*, 多田高: 胚性幹細胞がもつゲノム再プログラム化機構. 実験医学 19: 1511-1517, 2001.


多田高, 多田政子: EG細胞からみた生殖細胞のゲノムインプリンティング. 組織培養 21: 3-7, 1995.




Books (Japanese)


多田政子*, 多田高: 多能性幹細胞の再プログラム化活性. 中辻憲夫 編 「幹細胞・クローン研究プロトコール」第6章 核移植と再プログラム化.    羊土社p191-198, 2001.



PhD thesis

多田政子 「マウス初期胚発生および配偶子形成過程におけるインプリント遺伝子のDNAメチル化の変化:未分化ES、EGおよびEC細胞を用いたモデル系の研究」 (1996年3月) 北海道大学大学院地球環境科学研究科生態環境科学専攻 博士後期課程. 学位記番号(3941号)

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